Trimethyltin and cancer

Author: kama

August undefined, 2024

Weborganotins, such as trimethyltin and triethyltin compounds, can interfere with the way the brain and nervous system work. In severe cases, it can cause death. ... There is no evidence that tin or tin compounds cause cancer in humans. Studies in animals have not shown evidence of carcinogenicity for inorganic tin. A study in rats and another WebOct 7, 2011 · TRIM24 is a potent liver-specific tumour suppressor in mice and attenuates RARα-mediated transcription. TRIM28 (also known as TIF1β and KAP1) is highly …

ATSDR Tin ToxFAQs - Agency for Toxic Substances and …

WebJoel G. Pounds, Lee Ann McCue, Bobbie-Jo M. Webb-Robertson, 2010, Journal of proteome research. WebOct 19, 2024 · Three aromatase inhibitors are currently approved in the United States for breast cancer treatment: anastrozole (Arimidex), exemestane (Aromasin) and letrozole … raine and horne elite

Triethyltin - an overview ScienceDirect Topics

WebTrimethyltin and methyl mercury are both neurotoxicants that also have ototoxic properties. Of note is the fact that the chemically related triethyltin is a neurotoxicant but not an … WebJul 1, 2024 · Trimethyltin chloride (TMT) is a by-product in the synthesis of organotin, a plastic stabilizer. With the rapid development of industry, the occupational hazards caused by TMT cannot be ignored. ... Cytotoxicity in vitro of compounds has been estimated on human cancer (colon cancer HCT-116, lung carcinoma A549, breast cancer MCF-7 ... WebThus, agents that are able to interfere with their function increase the risk of cancer and/or infection. A series of triorganotins, (trimethyltin (TMT), dimethylphenyltin (DMPT), methyldiphenyltin (MDPT), and triphenyltin (TPT)) have been shown to decrease the lytic function of human NK cells. raine and horne double bay bondi beach

Chemotherapy for breast cancer - Mayo Clinic

Frontiers Organotins in Neuronal Damage, Brain …

WebFeb 1, 2009 · Earlier experiments have shown that As2O3 and TMT modulate calcium signalling in tumour cells (human neuroblastoma, human cervix adenocarcinoma) as well as in non-tumour cells (human embryonic... raine and horne forestvilleWebFeb 22, 2024 · Trimethyltin (TMT) is a potent neurotoxicant that affects various regions within the central nervous system, including the neocortex, cerebellum, and hippocampus. In the present study, ginsenoside Rd was investigated as a candidate neuroprotective agent in a primary hippocampal neuron culture and mouse models. TMT induced neurotoxicity in a … raine and horne five dock

"WebJun 11, 2024 · Trimethyltin (TMT) is an organotin compound that is considered a potent neurotoxicant and causes behavioral alterations as well as learning and memory impairment in mammals [5, 6]. Cognitive impairment, including memory loss and learning impairment, developed in experimental animals exposed to TMT, indicating severe hippocampal … " - Trimethyltin and cancer

Trimethyltin and cancer

Toxicity of trimethyltin and triethyltin to mallard ducklings

WebMar 1, 2024 · Trimethyltin induces apoptosis and necroptosis of mouse liver by oxidative stress through YAP phosphorylation. Yuqi Wang, Xiaojing Liu, Hongyuan Jing, ... PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling. Ying Bai, M. Ludescher, +13 authors H. Neubauer ... WebTrimethyltin chloride is an organotin reagent widely used in transferring trimethylstannyl groups onto the substrates to synthesize various organostannanes. Trimethylstannyl …

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WebAfter injecting TMT, animals show some behavioral changes such as seizures, aggressive behavior, self-biting, impaired working memory, and hyperactivity [4]. Studies show that TMT poisoning causes... WebTrimethyltin (TMT), a toxic organotin compound, induces neurodegeneration selectively involving the limbic system and especially prominent in the hippocampus. …

WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce morphologic changes in as little as 12 hours, with vacuolation of the outer hair cells visible by transmission electron microscopy. WebOct 6, 2024 · Chemotherapy as the primary treatment for advanced breast cancer. If breast cancer has spread to other parts of your body and surgery isn't an option, chemotherapy …

WebMay 22, 2024 · Trimethyltin was first described as a potent nephrotoxicant in two studies where this compound was orally administered in rats (28, 41). TMT induced rats to a renal … WebTo determine if this process would occur upon a direct injury to the dentate region, we exposed young, 21 day old male CD-1 mice to the hippocampal toxicant, trimethyltin …

WebMar 23, 2024 · Metformin and Cancer. Cancer is not a reported side effect of metformin. In fact, the American Diabetes Association and the American Cancer Society have reported … raine and horne ettalong beach nswWebA series of triorganotins, (trimethyltin (TMT), dimethylphenyltin (DMPT), methyldiphenyltin (MDPT), and triphenyltin (TPT)) have been shown to decrease the lytic function of human NK cells. TPT and MDPT were much more effective than DMPT or TMT at reducing lytic … raine and horne gulgong real estateWebDAPI染色液 (DAPI Staining Solution)是经过精心优化几乎适用于所有常见细胞和组织细胞核染色的染色液。. DAPI，即2- (4-Amidinophenyl)-6-indolecarbamidine dihydrochloride，也称DAPI dihydrochloride，分子式为C 16 H 15 N 5 ·2HCl ，分子量为350.25 ，CAS Number 28718-90-3。. DAPI是一种可以穿透细胞 ... raine and horne glen innes nswWebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce … raine and horne gawlerWebApr 6, 2024 · NiCl 2, a compound containing nickel, is extremely toxic to both humans and laboratory animals ( 1 ). Studies have shown that exposure to NiCl 2 is carcinogenic. NiCl 2 have the potential to cause cancer through various mechanisms, including oxidative stress, genomic DNA damage, epigenetic changes, and activation of transcription factors ( 2 ). raine and horne hobartWebJan 8, 2024 · Trimethyltin (TMT) Neurotoxicity. Trimethyltin is one of the most commonly used OTs in industry and agriculture, known for its role as a fungicide and plastic … raine and horne gawler saWebApr 11, 2024 · Ginsenoside compound K has been proven to have a range of anti-cancer activities against lung cancer, leukemia, breast cancer, and colon cancer [8,9,10,11]. Ginsenoside Rh2 shows anti-cancer activity against lung cancer and liver cancer by mediating the apoptosis of cancer cells and suppressing cell proliferation and migration [ … raine and horne gloucester nsw