Plzf transcription factor
WebApr 24, 2024 · Among these are transcription factors (TFs), an important class of proteins that regulate the occurrence, formation, and development of tumors. It is difficult for SMDs and macromolecular drugs to identify bioactive sites in TFs and hence for use as pharmacological inhibitors in targeting TF proteins. WebSignificance The mechanistic or mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that integrates various environmental signals/cues to regulate cell growth, proliferation, metabolism, and survival. The
Plzf transcription factor
Did you know?
WebJul 9, 2024 · PLZF directs the acquisition of effector properties, such as the upregulation of CD44 and production of effector cytokines 19, 20. Expression of PLZF directs the acquisition of effector... WebDec 16, 2015 · As a transcription factor, PLZF shows tight regulation in its cell-type-specific and stage-specific expression patterns. Emerging evidence shows that PLZF regulates the balance of self-renewal and differentiation …
WebFunction [ edit] This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger … WebThe PLZF transcription factor is essential for the innate phenotype of NKT cells. This report shows that PLZF is likewise responsible for the innate, NKT-like phenotype of Vγ1+Vδ6.3/Vδ6.4+ cells. TCR cross-linking induced PLZF expression in all polyclonal immature γδthymocytes, suggesting that agonist selection might be required for PLZF ...
WebThe promyelocytic leukaemia zinc finger (PLZF) protein belongs to the family of Krüppel-like zinc finger proteins. It is a transcriptional repressor involved in cell cycle control and has … WebJul 4, 2010 · PLZF (promyelocytic leukemia zinc finger; Zbtb16) has been identified as a key transcription factor involved in the development of NKT cells 5, 6, yet it remains unclear if and how such...
WebSep 19, 2008 · Selective Expression of PLZF in CD1d-Restricted NKT Cells. To identify the transcription factors involved in NKT cell development, we performed a microarray screen …
WebPLZF was shown to be phosphorylated by cdc2/Cyclin-B in vitro, which affected its DNAbinding ability to the promoter of many transcription factors such as c-Jun and GATA1 (Ball et al., 1999 ... long term use of methamphetamineWebApr 14, 2024 · NF-κB Response Moderation by Regulating the Transcription Factor PLZF Sadler et al. described a novel role for HAT1, namely, the acetylation of the transcriptional regulator promyelocytic leukemia zinc finger protein (PLZF), a critical cofactor of the NF-kB transcriptional complex that inhibits damaging inflammation [ 39 ]. long term use of mirtazapine icd 10WebJan 9, 2024 · The promyelocytic leukemia zinc finger (PLZF) transcription factor mediates a wide‐range of biological processes. Accordingly, perturbation of PLZF function results in a myriad of physiologic defects, the most conspicuous of which is … long term use of nicotine patch icd 10WebJul 30, 2015 · Among a number of transcription factors identified to date, NF-κB still remains the most prominent and studied factor for its diverse range of selective transcriptional activities. ... The transcriptional regulator PLZF is a critical co-factor that limits NF-κB-mediated inflammatory responses by maintaining a transcriptionally … hopital riaumont telephoneWebWe found that let-7 miRNAs targeted Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to post-transcriptionally regulate PLZF expression and thereby … long term use of naproxen side effectsWebOct 8, 2013 · Here, we show that the transcription factor Promyelocytic Leukemia Zinc Finger (PLZF) plays a critical role shaping patterns of neuronal differentiation by gating … hopital revelWebMay 23, 2004 · Zfp145 (also known as Plzf, promyelocytic leukemia zinc-finger) was identified by virtue of its involvement in chromosomal translocations with the gene Rara (retinoic acid receptor-α), which is... long term use of naproxen sodium