Fnip2
WebThe deduced 1,114-amino acid protein shares 49% identity with FNIP1. Quantitative real-time PCR detected variable FNIP2 expression in most tissues examined, with highest … WebAnti-FNIP2 antibody Description Rabbit polyclonal to FNIP2 Host species Rabbit Specificity ab106611 is predicted to not cross-react with FNIP1. Tested applications Suitable for: …
Fnip2
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WebNov 22, 2024 · To determine the lysosomal function of FLCN, we reconstituted the human lysosomal FLCN complex (LFC) containing FLCN, its partner FLCN-interacting protein 2 (FNIP2), and the RagA GDP:RagC GTP GTPases as they exist in the starved state with their lysosomal anchor Ragulator complex and determined its cryo-electron microscopy … WebFNIP2 folliculin interacting protein 2 [ (human)] Gene ID: 57600, updated on 6-Nov-2024. Summary. This gene encodes a protein that binds to the tumor suppressor folliculin and …
Webin kidney, the Fnip2 expression level, which is commensurate with that of Fnip1, might maintain Fnip function in Fnip1-deficient kidneys, and therefore, double inactivation … WebMar 3, 2024 · FLCN forms complexes with two large interacting proteins, FNIP1 and FNIP2. Structural studies have shown that both FLCN and FNIPs contain longin and differentially expressed in normal versus neoplastic cells (DENN) domains, typically involved in the regulation of small GTPases.
WebFNIP1 and FNIP2 were identified as proteins interacting with tumor suppressor folliculin (FLCN) (1-3). FNIP1 and FNIP2 directly associate with AMPK, which indicates that they …
WebFeb 7, 2024 · Folliculin-interacting protein 1 and 2 (FNIP1 and FNIP2) play critical roles in preventing renal malignancy through their association with the tumor suppressor FLCN. Mutations in FLCN are associated with Birt-Hogg-Dubé (BHD) syndrome, a rare disorder with increased risk of renal cancer.
WebT carriers of rs2291007 have decreased expression of FNIP2 in peripheral blood, and importantly, FNIP2 mRNA levels strongly associate with decreased obesity-related … crypto whales watchWebOct 31, 2024 · FNIP2 gene expression significantly correlated with both FNIP1 and FLCN (Additional file 1: Fig. S3B) and we observed associations between the levels of FLCN expression and increased weight, BMI, fat mass, visceral fatness, waist and hip circumferences, DBP, and blood levels of glucose, leptin, and triglycerides; and … c thread函数WebGermline mutations in the Folliculin (FLCN) tumor suppressor gene cause Birt-Hogg-Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing carriers to kidney … crypto whales waveWebView FNIP2 mouse/human homology from Alliance Direct with: genes, location, sequences, associated human diseases c train to airportWeb1 day ago · Unlike the T-carrying allele, which blocks the expression of metabolic FNIP2 enzymes, the C-carrying variant optimizes its expression. Fernandez et al. found that thin mice had more FNIP2 enzymes in their blood, compared to the mice with excess weight. This suggests that the prevalence of these enzymes correlates with thinness, and the … c sharps 1885 high wallhttp://shanghaipasteur.cas.cn/zhxw/202406/t20240624_6715152.html c sharp online compiler gdbWebIdiopathic inflammatory myopathy (IIM) is the umbrella term including dermatomyositis (DM), polymyositis (PM), overlap myositis (OM), sporadic inclusion body myositis (IBM) and necrotising autoimmune myopathy (NAM), also known … c style brackets